The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model
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The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model.
We investigated the effects of amla (Emblica officinalis Gaertn.) on fructose-induced metabolic syndrome using a rat model. Male Wistar rats were fed a high-fructose (65 %) diet or standard chow for 1 week, and treated with an ethyl acetate (EtOAc) extract of amla, a polyphenol-rich fraction, at 10 or 20 mg/kg body weight per d, or vehicle, for 2 weeks. Serum glucose, TAG, total cholesterol and...
متن کاملAmla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process.
Amla (Emblica officinalis Gaertn.) is widely used in Indian medicine for the treatment of various diseases. We have investigated the effects of amla on the lipid metabolism and protein expression involved in oxidative stress during the ageing process. SunAmla or ethyl acetate extract of amla, a polyphenol-rich fraction, was administered at a dose of 40 or 10 mg/kg body weight per d for 100 d to...
متن کاملInfluence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats.
The effects of amla on low-density lipoprotein (LDL) oxidation and cholesterol levels were investigated in vitro and in vivo using Cu(2+)-induced LDL oxidation and cholesterol-fed rats. SunAmla and ethyl acetate (EtOAc) extract of amla significantly inhibited thiobarbituric acid (TBA)-reactive substance level in the Cu(2+)-induced LDL oxidation and the effects were stronger than those of probuc...
متن کاملProtective effect of curcumin in fructose-induced metabolic syndrome and in streptozotocin-induced diabetes in rats
Objective: The aim of this study was to investigate the effect of pre-treatment with curcumin on metabolic changes induced by two different pathophysiological mechanisms in rats (fructose diet and streptozotocin (STZ)-induced diabetes mellitus). Materials and Methods: Five groups with 10 rats per group were investigated: control group (healthy rats), fructose diet groups without any pre-treatme...
متن کاملAntinociceptive property of Emblica officinalis Gaertn (Amla) in high fat diet-fed/low dose streptozotocin induced diabetic neuropathy in rats.
Diabetic neuropathic pain is an important microvascular complication in diabetes mellitus and oxidative stress plays a vital role in associated neural and vascular complications. The present study investigated flavonoid rich fruit extract (ethyl acetate:methanol fraction) of E. officinalis (10 mg/kg), in type II diabetes (high fat diet fed/low dose streptozotocin) induced diabetic neuropathy in...
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ژورنال
عنوان ژورنال: British Journal of Nutrition
سال: 2009
ISSN: 0007-1145,1475-2662
DOI: 10.1017/s0007114509991978